Lugoff was named for Count Lugoff (Loo'goff), a Russian architect, who helped with the construction of the Seaboard Air Line Railway in 1899. Lugoff is one of numerous stations in Kershaw County for the Seaboard Railway. Count Lugoff brought numerous Russian workers to help with the construction, but what became of them afterwards is unknown.
Lugoff is the birthplace of Brook Benton, best known for recording "Rainy Night in Georgia" and is the home of the multi-million dollar Invista Plant, formerly known as DuPont. Lugoff is situated on Highway 1 and is four miles west of Camden